Chemoselective probes for advanced metabolomics analysis.
Samhälle & välfärd
Daniel Globisch, Weifeng Lin
Our new quantitative methodology for analysis in the low attomole range holds high potential for enabling earlier detection of diseases. The unique chemoselective probes are immobilized to magnetic beads for facile handling and removal of interferences, and allow for advanced mass spectrometric analysis of metabolites in biological samples.
These quantitative Sensitive CHEmoselective MetAbolomics (Quant-SCHEMA) probes extend the scope of standard global metabolomics with up to 1 million higher sensitivity, which facilitates analysis of e.g. rare metabolites produced by the gut microbiome and elucidate their link to disease development.